Pen Reyes
Supervisor:
Collaborators:
Current as of November 2009 |
I joined the Tanaka lab in late 2006, and have since been working to earn a postgraduate degree here in UNSW in the School of BABS through the UIPA and funding from the Faculty of Science. I am also a member of the Evolution and Ecology Research Centre. The broad goal of my project is to understand the evolution of molecular markers in bacterial pathogens. Based on molecular data from epidemiological studies of tuberculosis, I developed a model of evolution for spoligotypes in tuberculosis, together with Dr Mark Tanaka and Dr Andrew Francis. Details of this work are in this research article. This model can be applied to construct "spoligoforests" to visualise relationships among tuberculosis spoligotypes. An example of a spoligoforest: (see our poster where this figure was featured in the EERC page)
An implementation of spoligoforests can be accessed in spolTools. Other programs in spolTools are described in this applications note. I am currently studying the evolution of microsatellites in bacteria, specifically to develop a model for the evolution of tuberculosis VNTRs. Publications Reyes JF, Francis AR, Tanaka MM. Models of deletion for visualising bacterial variation: an application to tuberculosis spoligotypes. BMC Bioinformatics. 2008 vol. 9 pp. 496 Tang C, Reyes JF, Luciani F, Francis AR, Tanaka MM. spolTools: online utilities for analyzing spoligotypes of Mycobacterium tuberculosis complex. Bioinformatics. 2008 vol 24 (20) pp. 2414 |
Jacaranda outside UNSW BABS in late spring
A rainbow over Randwick outside UNSW Gate 9 in winter
The huge metal ball in the UNSW main walk
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